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The Hindu- Thursday, November 09, 2000

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Chewing pan masala causes oral cancer

INDIA WILL be heading for an epidemic of oral cancer unless there is a check on the consumption of pan masala, an expert at the Cancer Research Institute in Mumbai has warned.

R. A. Bhisey, who analysed the various studies conducted on pan masala in different laboratories in India, says that available results ``clearly indicate that pan masala is a potential human carcinogen''.

Reporting her findings in the Proceedings of the Indian National Science Academy, Bhisey said that survey of relevant literature indicates that pan masala constituents ``individual and in the mixture form'', induce gene mutations and chromosomal damage and give rise to a variety of tumour in rats.

She said large scale studies using patterns and controls have ``revealed a direct relationship between chewing pan masala and oral submucous fibrosis (OSF)'', a condition that is a precursor to oral cancer. Bhisey said ``clinical investigations have shown prevalence of area nut and pan masala chewing habits in patients suffering from OSF.

``The demonstration of increased genotoxic risk in users of pan masala and its association with impaired liver function and OSF indicates that pan masala habit can cause significant health hazards in the Indian population'', the expert said.

According to her report, the epidemiological data suggest OSF is likely to reach an epidemic level in the next decade.

``This situation is expected to increase the incidence of oral cancer - the most important cancer in India'', she said.

-         PTI

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